LRP1 as a promising therapeutic target for gastrointestinal tumors: Inhibiting proliferation, invasion and migration of cancer cells

Gastrointestinal (GI) cancers are the most common types of tumors worldwide. The lack cancer biomarkers and targeted drug resistance barriers to achieving effective therapy. Low‑density lipoprotein receptor‑related protein 1 (LRP1) is a transmembrane that has multiple functions due its ability recognize different ligands; however, role LRP1 in GI cells remains unclear. present study aimed investigate tumors. Cancer Genome Atlas database was used analyze potential correlation between expression prognosis patients with cancer. Bioinformatics analysis utilized simultaneously validated at cellular level through western blot experiments. expressed high levels HGC‑27, HepG2 BxPC‑3 cells. knocked down using lentivirus‑mediated shRNA effects on biological were observed. knockdown suppressed proliferation, invasion migration inhibited CD36 gene cells, suggesting may be novel target for treatment